Foamy Virus Envelope Glycoprotein-Mediated Entry Involves a pH-Dependent Fusion Process

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Foamy virus envelope glycoprotein-mediated entry involves a pH-dependent fusion process.

In general, enveloped viruses use two different entry strategies and are classified accordingly into pH-dependent and pH-independent viruses. Different members of the retrovirus family use one or the other strategy. Little is known about the uptake of foamy viruses (FV), a special group of retroviruses, into the target cells. In this study, we examined the pH dependence of FV entry by analyzing...

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Retroviral Entry Mediated by Receptor Priming and Low pH Triggering of an Envelope Glycoprotein

Avian leukosis virus (ALV) has been used as a model system to understand the mechanism of pH-independent viral entry involving receptor-induced conformational changes in the viral envelope (Env) glycoprotein that lead to membrane fusion. Here, we report the unexpected finding that ALV entry depends on a critical low pH step that was overlooked when this virus was directly compared to the classi...

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Role of the stable signal peptide of Junín arenavirus envelope glycoprotein in pH-dependent membrane fusion.

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Role of the Stable Signal Peptide of Junı́n Arenavirus Envelope Glycoprotein in pH-Dependent Membrane Fusion

The envelope glycoprotein of the arenaviruses (GP-C) is unusual in that the mature complex retains the cleaved, 58-amino-acid signal peptide. Association of this stable signal peptide (SSP) has been shown to be essential for intracellular trafficking and proteolytic maturation of the GP-C complex. We identify here a specific and previously unrecognized role of SSP in pH-dependent membrane fusio...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 2003

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.77.11.6587.2003